NFL Week 13: Preview, Predictions, and Analysis of Key Games

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Detailed Analysis of the NFL Week 13 Matchups of 2025

NFL Week 13 for the 2025 season presents intriguing matchups. The 49ers will visit Shedeur Sanders and the Browns, the Raiders, now without Chip Kelly, will face the Chargers, and the Broncos will seek their ninth consecutive victory. Below, an in-depth analysis of each game. Alofoke Deportes brings you everything you need to know. Our reporters offer you information from the locker room, key statistics, and predictions for each match. In addition, our data analyst, Seth Walder, shares his bold predictions, and fantasy analyst Eric Moody provides valuable information. Get ready for a week full of excitement, culminating in the “Monday Night Football” game between the Giants and the Patriots.
  • CHI-PHI
  • HOU-IND
  • LAR-CAR
  • ARI-TB
  • SF-CLE
  • JAX-TEN
  • ATL-NYJ
  • NO-MIA
  • MIN-SEA
  • BUF-PIT
  • LV-LAC
  • DEN-WSH
  • NYG-NE
(Match times are on Sunday, unless otherwise noted.)

Analysis of the Matches

Texans (6-5) vs. Colts (8-3)

Time: 1 p.m. ET | CBSBetting Line: IND -4.5 (44.5 O/U)What’s being said about the Texans: C.J. Stroud is likely to return after missing three games due to a concussion. The Texans survived without him, and now, with Stroud back, Houston is looking to secure a playoff spot or even win the division if they beat the Colts in their two direct matchups. – DJ Bien-AimeWhat’s being said about the Colts: Indianapolis has only played two divisional games, making this the first of four AFC South games in the last six games. Houston’s dominant defense represents one of the toughest tests the Colts have faced. – Stephen HolderKey statistic: Texans’ Will Anderson Jr. has recorded sacks in six straight games, tying Mario Williams (2007) for the second-longest streak in Texans history.Bold Prediction: Alec Pierce, Colts wide receiver, will have a reception of over 40 yards. – WalderFantasy Information: The Texans’ defense has been tough on opposing quarterbacks, allowing only 11.5 fantasy points per game, the fewest in the league. The Colts should rely on Jonathan Taylor in the running game.Featured Bet: The Colts have a 5-1 ATS record at home.

Predictions:

  • Maldonado: Colts 22, Texans 10
  • Moody: Colts 24, Texans 19
  • Walder: Colts 23, Texans 17
  • FPI: IND, 64.3% (for an average of 5.7 points)
Required Readings: Colts quarterback Daniel Jones needs to regain his form against the Texans.

Rams (9-2) vs. Panthers (6-6)

Time: 1 p.m. ET | FoxBetting Line: LAR -10.5 (44.5 O/U)What’s being said about the Rams: Davante Adams has 12 receiving touchdowns, the most in the NFL. He’s a problem at the line of scrimmage. – Sarah BarshopWhat’s being said about the Panthers: Rico Dowdle posted a cryptic emoji on X after only six carries in the loss to the 49ers. Ball control will be crucial against the Rams, who are averaging 30.5 points during their six-game winning streak.Key Statistic: The Panthers are 3-1 when Bryce Young records at least 6.0 yards per attempt. They are 3-4 when he records less than 6.0 YPA.Bold Prediction: Young will have fewer than 10 pass attempts in the first half. – WalderFantasy Information: Stafford is playing some of the best football of his career. He has a couple of elite receivers in Puka Nacua and Adams, and leads the league in red zone pass attempts. – MoodyFeatured Bet: The Rams have an 8-2 ATS record as favorites.

Predictions:

  • Maldonado: Rams 27, Panthers 12
  • Moody: Rams 34, Panthers 20
  • Walder: Rams 27, Panthers 13
  • FPI: LAR, 71.4% (by an average of 8.6 points)
Required Readings: Young, Panthers can’t repeat mistakes against the Rams. NFL suspends Panthers’ Trevon Moehrig for one game.

Cardinals (3-8) vs. Buccaneers (6-5)

Time: 1 p.m. ET | FoxBetting Line: TB -3.5 (44.5 O/U)What’s being said about the Cardinals: Michael Wilson is expected to have another significant role in the offense, regardless of whether Marvin Harrison Jr. returns this week. – Josh WeinfussWhat’s being said about the Buccaneers: The Bucs are in the midst of a three-game losing streak, but Baker Mayfield is dealing with a low-grade sprain in his left shoulder. They need this win to gain ground in the NFC South. – Jenna LaineKey statistic: The Cardinals’ Trey McBride has had 13 consecutive games with five or more receptions, tying the longest streak in franchise history.Bold Prediction: Bucky Irving, Buccaneers running back, will record 100 or more rushing yards. – WalderFantasy information: Wilson has had an elite target volume, with 18 targets in Week 11 and 15 more in Week 12. – MoodyFeatured Bet: The Buccaneers’ four home games have gone over the total.

Predictions:

  • Maldonado: Buccaneers 23, Cardinals 17
  • Moody: Cardinals 27, Buccaneers 17
  • Walder: Buccaneers 27, Cardinals 16
  • FPI: TB, 62.9% (by an average of 5.2 points)

49ers (8-4) vs. Browns (3-8)

Time: 1 p.m. ET | CBSBetting Line: SF -4.5 (36.5 O/U)What’s being said about the 49ers: San Francisco hasn’t won in Cleveland since 1984. Browns defensive coordinator Jim Schwartz’s defense has given Kyle Shanahan’s offense trouble. – Nick WagonerWhat’s being said about the Browns: The Browns are sticking with Shedeur Sanders after he helped spark Cleveland’s passing game in his first start. Sanders will have another week to improve and try to pull off an upset at home. – Daniel OyefusiKey statistic: Myles Garrett of the Browns has achieved 14.0 sacks in his last five games, the most by any player in a five-game span since 1982.Bold prediction: Browns wide receiver Jerry Jeudy will record six or more receptions. – WalderFantasy information: The Browns’ defense allows the second-fewest fantasy points to running backs. – MoodyFeatured Bet: The 49ers are 5-0 and 4-1 ATS against teams with losing records.

Predictions:

  • Maldonado: 49ers 21, Browns 17
  • Moody: 49ers 31, Browns 16
  • Walder: 49ers 23, Browns 7
  • FPI: SF, 75.9% (by an average of 11 points)
Required Readings: Tracking Garrett’s pace for the NFL single-season sack record.

Jaguars (7-4) vs. Titans (1-10)

Time: 1 p.m. ET | CBSBetting Line: JAX -6.5 (41.5 O/U)What’s being said about the Jaguars: The Jaguars have recorded nine sacks in the last two weeks and the most quarterback hits in the league. The running attack is emerging at the right time because the Titans quarterback, Cam Ward, is the most sacked quarterback in the NFL. – Michael DiRoccoWhat’s being said about the Titans: Ward continues to develop as a passer. The Jaguars’ defense is allowing 9.6 points per game in the fourth quarter, the twenty-ninth worst in the league. – Turron DavenportKey statistic: Ward set the best marks in Total QBR in each of the last two weeks after starting his career with nine straight games with a QBR below 40.Bold Prediction: Jaguars wide receiver Parker Washington will record his third career game of 90+ receiving yards. – WalderFantasy information: Travis Etienne Jr. and the Jaguars’ running game could be the focus. – MoodyFeatured Bet: The Titans have covered three consecutive games.

Predictions:

  • Maldonado: Jaguars 28, Titans 27
  • Moody: Jaguars 25, Titans 13
  • Walder: Jaguars 24, Titans 14
  • FPI: JAX, 66.9% (by an average of 6.9 points)
Required Readings: Armstead is giving back to Jacksonville on and off the field. Ward, his best game yet? The number 1 pick continues to progress. Lawrence of the Jags owns the interceptions, but he will not “play with fear”.

Falcons (4-7) vs. Jets (2-9)

Time: 1 p.m. ET | FoxBetting Line: ATL -2.5 (39.5 O/U)What’s being said about the Falcons: Defensive coordinator Jeff Ulbrich will return to MetLife Stadium, where he was the Jets’ defensive coordinator for four seasons and then interim coach for part of 2024. – ESPN
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