The NFL Week 6 for the 2025 season presents promising matchups. After a 206-yard rushing game last week, Panthers running back Rico Dowdle will look to repeat his performance against the Cowboys, his former team. The Buccaneers will host the 49ers for a matchup between 4-1 teams. And the Lions visit the Chiefs’ Arrowhead Stadium for the second time in three seasons. In Alofoke Deportes, we have everything you need to know. Our NFL reporters will take you to the locker room with the best things they heard this week, and the Alofoke Deportes research team provides a key statistic and a betting nugget for each game. In addition, statistics analyst Seth Walder makes a bold prediction for each matchup, and fantasy analyst Eric Moody shares fantasy football information. We also have Football Power Index (FPI) matchup quality ratings and game projections, and three analysts, Pamela Maldonado, Moody, and Walder, give us their final score picks for each game. Here is the complete Week 6 schedule, culminating with a “Monday Night Football” doubleheader between the Bills and the Falcons (on ESPN) and the Bears at the Commanders (on ABC). (Game times are Sunday unless otherwise noted).
Contents
Match Summary
- NYJ-DEN
- LAR-BAL
- SEA-JAX
- ARI-IND
- LAC-MIA
- DAL-CAR
- CLE-PIT
- NE-NO
- TEN-LV
- SF-TB
- CIN-GB
- DET-KC
- BUF-ATL
- CHI-WSH
Jets vs. Broncos
9:30 a.m. ET | NFL Network | Matchup Rating: 44.9/100 What we’re hearing about the Jets: DT Quinnen Williams said it best: “We’re 0-5 and the defense has been the problem, the reason we’re 0-5.” The Jets haven’t managed any takeaways and only three sacks in the last four games. Pass rush was an emphasis in practice this week, but a breakthrough against the Broncos won’t be easy. They’ve allowed only five sacks this season. — Rich Cimini What we heard about the Broncos: The Broncos departed for London a few hours after their victory over Philadelphia, coach Sean Payton’s most important victory in Denver. Payton said he put aside any idea that playing the Jets at Tottenham Stadium is some kind of trap game for the 3-2 Broncos. “Every week is the ability to refocus on the next challenge,” Payton said. “… These guys understand that in our league, it’s different from college. We don’t have the opportunity to play against an I-AA or FCS school. These are all professional teams, and we’ll handle it that way.” — Jeff Legwold Statistical note: Broncos quarterback Bo Nix was limited to just 60 passing yards in last season’s 10-9 victory over the Jets, the only time in his career he has been held under 130 passing yards. — Alofoke Deportes Investigation Bold prediction: Jets running back Breece Hall will have one or zero receptions. The Jets throw to their running back 26% of the time, the fourth-most of any team. But the Broncos’ man-focused defense allows a lower target rate to running backs (12%) than any other team. — Walder Injuries: Jets | Broncos Fantasy nugget: Jets quarterback Justin Fields finished with 25.9 fantasy points in Week 5. However, he faces a Broncos defense that has allowed the fewest fantasy points and yards per carry per game to quarterbacks this season. Fantasy managers should consider trading for a streaming player this week. — Moody Pick by Maldonado: Broncos 31, Jets 6 Moody’s Pick: Broncos 30, Jets 17 Pick of Walder: Broncos 22, Jets 12 FPI Prediction: DEN, 70.8% (by an average of 8.3 points) Must-reads from the matchup: Jets vow to keep fighting despite being the NFL’s only winless team … How the Broncos, Elway built an NFL general manager treeRams vs. Ravens
1 p.m. ET | Fox | Matchup Rating: 74.3/100 What we’re hearing about the Rams: Through five weeks, Rams quarterback Matthew Stafford leads the league with 1,503 passing yards and is just 50 yards away from surpassing Dan Marino (61,361) for the ninth-most passing yards in NFL history. The Ravens have allowed 177 points this season, the most in a five-game span in franchise history, according to Alofoke Deportes research. Baltimore is also allowing an average of 262.6 passing yards per game, the second-worst mark in the NFL. — Sarah Barshop What we’re hearing about the Ravens: Running back Derrick Henry has been held to 50 rushing yards or less in four straight games, matching the worst streak of his career. It’s important for Henry to get back to normal for the Ravens, who are 10-1 when Henry produces more than 90 rushing yards. But the Rams, who have the NFL’s No. 10 run defense, have only allowed one running back to get more than 90 rushing yards this season (Tony Pollard). “We have the best running back in the game,” Ravens center Tyler Linderbaum said, “so we have to find a way to be better.” — Jamison Hensley Statistic to consider: The Ravens were outscored by more than 17 points in each of their last two games. They have never lost three consecutive games by at least three scores in franchise history. — Alofoke Deportes Research Bold prediction: The Rams will complete multiple passes of over 40 yards. Through five weeks, the Rams have the highest air yards per attempt in the league with 8.5, and the Baltimore defense is allowing 8.0 air yards per target (the fourth most). Although I believe the Ravens’ defense will eventually figure it out, the best bet for now is that it will continue to struggle in the short term. — Walder Injuries: Rams | Ravens
Seahawks vs. Jaguars
1 p.m. ET | Fox | Matchup Rating: 57.5/100 What we’re hearing about the Seahawks: The Seahawks’ defense was lit up in Week 5 due in large part to its inability to pressure Bucs quarterback Baker Mayfield, who was only hit once in 38 dropbacks. Next up is Jacksonville’s Trevor Lawrence, who has only been sacked six times in five games. Coach Mike Macdonald attributed the Jaguars’ ability to stay on schedule and avoid pure dropback situations as a factor, along with Lawrence’s quick decisions. “Receivers are getting open and he’s throwing the ball on time,” Macdonald said. “He’s throwing with accuracy and they’re protecting him.” — Brady Henderson What we’re hearing about the Jaguars: The Jaguars’ offensive strength is their running game (fifth in the NFL with 137 rushing yards per game) and they will face their toughest test of the season against Seattle, which has the third-best run defense in the league (83 yards per game). Running back Travis Etienne Jr. described the Seahawks’ front as game wreckers and said they present “a lot of confusion.” The Jaguars are likely to be without center Robert Hainsey (hamstring), so seventh-round rookie Jonah Monheim will replace him, a difficult task for his first start. — Michael DiRocco Statistic to consider: The Jaguars have 14 interceptions this season, the most in the NFL. — Alofoke Deportes Research Bold prediction: The Seahawks release quarterback Sam Darnold and have him throw 40 pass attempts. Yes, even against a Jaguars defense that ranks third in EPA per allowed dropback. The Seahawks have been much more efficient passing than running this season (.28 EPA per play to minus 0.07) and need to lean more on that part of their game. Also, the Jaguars have a new CB in Greg Newsome II, who might still be getting used to the defense. — Walder Injuries: Seahawks | Jaguars Fantasy nugget: Against the Chiefs, Travis Hunter had a season-high in offensive plays and also recorded a career-high in receiving yards for the second consecutive game. The Seahawks’ secondary is a mid-group unit and just allowed Bucs rookie WR Emeka Egbuka to score 31.3 fantasy points against them. Hunter could have a breakout performance. — Moody Pick of Maldonado: Seahawks 17, Jaguars 16 Moody’s Pick: Jaguars 27, Seahawks 24 Pick of Walder: Seahawks 30, Jaguars 24 FPI Prediction: JAX, 50.2% (by an average of 0.1 points) Must-read matchups: Seahawks QB Darnold showed potential in Week 5 loss … Jaguars LB Lloyd is flourishing in the new defense … Jaguars get Newsome, send Campbell to BrownsCardinals vs. Colts
1 p.m. ET | Fox | Matchup Rating: 58.1/100 What we’re hearing about the Cardinals: Marvin Harrison Jr. has finally found a rhythm in the last two weeks, and it has resulted in a significant increase in explosive plays. In Week 4 and Week 5 combined, both losses, Harrison was responsible for seven explosive plays, compared to just two in the first three games. This week is another opportunity for Harrison to add to his total, as the Colts have given up 23 explosive passes this season, 12 in the last two games. “I mean, it helps to catch explosives,” Harrison said. “I think in both games, that certainly helps and then you get a rhythm from there.” — Josh Weinfuss What we’re hearing about the Colts: This will be an interesting matchup because the Colts are number 2 in points per game (32.6) and the Cardinals are allowing only 19.2 points per game. Can the Colts find solutions for a defense that has limited the 49ers and Seahawks in recent weeks? It will be one of the most important tests for quarterback Daniel Jones and the Colts, who have been creating weekly fireworks. In particular, the Cardinals have not allowed a 100-yard rushing performance, while Colts running back Jonathan Taylor is averaging 96 yards per game. — Stephen Holder Statistics to take into account: Jones leads the NFL in QBR outside the pocket when pressured and on third down. He is second in total QBR this season (79.6), behind Seahawks quarterback Sam Darnold. — Alofoke Deportes Research Bold prediction: The Colts will average less than 4.0 yards per carry. They face a Cardinals defense that has allowed the lowest EPA per designed carry this season, and that could put a real strain on the Colts’ run-focused offense. — Walder
